A suspension of 1.0 g LAH in 100 mL warm THF was stirred under a N₂ atmosphere and heated to a gentle reflux. To this there was added, dropwise, a solution of 1.2 g 1-(2,5-dimethoxy-4-isopropylthiophenyl)-2-nitropropene in 20 mL anhydrous THF. This mixture was held at reflux for 1 day, then stirred at room temperature for 2 days. There was then added, slowly and with caution, 1 mL of H₂O, followed by 1 mL of 15% NaOH, and finally by another 3 mL of H₂O. Stirring was continued until the reaction mixture became white and granular, then all solids were removed by filtration and the filter cake was washed with additional THF. The filtrate and washings were combined, and the solvent removed under vacuum to give 1.1 g of residue which was an almost white oil. This was dissolved in 6 mL IPA, neutralized with concentrated HCl (10 drops were required) and then diluted with 200 mL anhydrous Et₂O. The resulting slightly turbid solution was clarified by filtration through a sintered glass filter, and the clear and slightly yellow filtrate was allowed to stand. A fine white crystalline product slowly separated over the next few h. This product, 2,5-dimethoxy-4-isopropylthioamphetamine hydrochloride (ALEPH-4) was removed by filtration, and after washing with Et₂O and air drying, weighed 0.5 g and had a mp of 146–147 °C, with prior sintering at 144 °C.

(with 8 mg) “There was without question a plus two, but none of the edges of unreality that are part of . The sounds that are just outside of my hearing are intriguing, and distract me from the eyes-closed imagery that is just barely possible with music while lying down. But, going outside, there were no obvious sources of the sounds that I heard. Could I drive? I suspect so. I took a shower and did just that—I drove to San Francisco without incident, and walked amongst the many strange faces on the downtown streets.”

(with 12 mg) “The experience was very intense but completely under control except for a twenty minute period right in the middle of it. I had to get away from everything, from everyone. There was a sense of being surrounded and moved in upon that was suffocating. I was weighed down with everything—physical, psychic, emotional. My clothes had to come off, my hair had to be released, my shoes went, I needed to move away from where I was, to somewhere else, to some new place, any new place, with the hope that my other old place wouldn’t follow me. Pretty soon I found I was myself, I could breathe again, and I was OK. Rather sheepishly, I dressed and rejoined the group. The rest of the day was spectacular, but those few minutes were scary. What if I couldn’t have escaped?”